In the second installment of the Dhoom series, Jai and Ali are back as the buddy cops on their toughest job so far. "Mr.A" is an international thief who has planned to steal a priceless artifact in Mumbai and the police have got to nab him. But Mr.A manages to steal the artifact and elude the police. He finds his match in Sunehri and they form a partnership. They move on to Rio for their next job, with Jai and Ali hot on their trail. Mr.A whose actual name is Aryan, and Sunehri are drawn towards each other but little does Aryan know of Sunehri's little secret.
At a Bangkok 'Asian Bhai Meet' the Godfather meets with several gangsters, reviews the reduction in revenue, and decides to induct fresh blood. While Fursat Lala decides to hand-over this task to his son, Zac; Mungi Lal, a bachelor, has no heir, save for an long-estranged maternal nephew, Kamal, and is asked to find him and include him in this gang within 30 days. Mungi and his associate, Jignesh, head out to Mumbai in an effort to locate his estranged sister, Angoori, and her son - in vain - as there is no trace of the duo. He recruits the services of Private Detective Johnny English and instructs him to locate Kamal. Johnny does locate him and takes him to meet with Mungi - a move that will result in nothing but hilarious chaos when Mungi tells him that he has already located Kamal. Things get even more confusing after a woman shows up - also claiming to be Kamal!!